Silhouette Universität Witten/Herdecke
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Wolf-Dieter Grimm
Univ.-Prof. Dr. Dr. med. dent.

Wolf-Dieter Grimm

Fakultät für Gesundheit (Department für Zahn-, Mund- und Kieferheilkunde)
Abteilung für Parodontologie
Professor emeritus

Tel.:
+49 (0)2302 / 926-608
Bereich:
Gesundheit
Ort:
Alfred-Herrhausen-Straße 44
58455 Witten
Raum:
ZBZ
Fax:
+49 (0)2302 / 926-661
Lebenslauf
2019 Visiting Professor, Cell Technology Lab, North Western State Medical University, St. Petersburg, Russian Federation
2016 Visiting Professor, Stem Cell Lab, Institute of Regenerative Medicine, Stavropol State Medical University, Russian Federation
2014 - 2017 Distinguished Gottfried Herder Exchange Program Professor of Stomatology (Germany) at Stavropol State Medical University (Russian Federation)
2010 Senior Professor of Periodontology: University of Witten, Faculty of Health, Department of Dentistry
2010 Privat Practice “Praxisteam Hasslinghausen” spezialized on Advanced Periodontology and Dental Implantology
1992 – 2009 Chair and Professor of Periodontology: University of Witten, Faculty of Dental Medicine, Department of Periodontology
1991 – 1996 Vice Dean of Medical Affairs, University of Witten, Faculty of Dental Medicine
1985 – 1990 Chair and Associate Professor, Academy of Medical Postgraduating, Dental School, Department of Periodontology and Dental Research, Schwerin
1982 – 1985 Chair and Associate Professor, Academy of Medical Postgraduating, Dental School, Department of Dental Research, Schwerin
1978 – 1982 Chair and Associate Professor, Department of Medical Informatics, Medical School, University of Dresden, Medical Academy
1978 – 1981 Vice Director and Associate Professor, Computer Centre, Medical Hospital, University of Dresden, Medical Academy 1977 – 1978 Assistant Professor, Department of Periodontology, Dental School, University of Dresden, Medical Academy

 

Honors, Grants and Awards

  • 2001 Colgate-Research Award, basic research in Dentistry (Gold Medal)
  • 2003 Colgate-Research Award, basic research in Dentistry (Bronze Medal)
  • 2007 Dissertation - 1.Award („Nachweis und Quantifizierung von Parodontitis-assoziierten Sulfat reduzierenden Bakterien (SRB) mittels quantitativer PCR“), University Witten/Herdecke
  • 2008 Dissertation - 1. Award „Enamel Matrix Derivative stimulates apoptosis of T cell-lymphocytes in vitro. University Witten/Herdecke, Faculty of Dental Medicine, awarded by Heraeus-Kulzer

Patent
PCT/EP2006/066221 “A post-natal periodontal-derived neural stem cell”

Publikationen
  • Grimm, W.-D., P. Cichon, H. van der Hoeven, P. S. Langendijk, F. Smith, M. Worley, I. Schmitz, S. Offenbacher. The influence of Sulfate Reducing Bacteria (SRB) colonization of two different bioresorbable barrier membranes for guided tissue regeneration. A case-controlled microbiological and clinical study over 18 months. Int J Periodontics Restorative Dent 20: 2000, 93-99. IF: 1.702
  • Langendijk-Genevaux, P.S., W.-D. Grimm, J.S. van der Hoeven. Sulfate-reducing bacteria in relation with other potential periodontal pathogens. J Clin Periodontol 28: 2001, 1151-1157. IF: 3.549
  • Grimm, W.-D., W. H. Arnold, M. Dietrich, H. Morgner. Three-Dimensional Surface Pattern and Chemical Composition of Mucosal Titanium Implant Compartments. Mater Trans 43: 2002, 3036-3042. IF: 0.795
  • Widera D, Grimm W-D, Moebius J, Piechaczek C, Gaßmann G, Wolff N, Thévenod F, Kaltschmidt C, Kaltschmidt B. Highly Efficient neural differentiation of human somatic stem cells, isolated via minimally-invasive periodontal surgery. Stem Cells Dev 2007; 16 (3):447-60. IF: 4.146
  • Widera D, Grimm WD, Möbius JM, Dannan A, Becher S, Mikenberg I, Piechaczek C, Gassmann G, Kaltschmidt B: Human periodontium-derived neural stem cells: chance or risk? Regenerative Medicine 2007, 2:3-61. IF: 3.873
  • Gassmann G, Schwenk B, Entschladen F, Grimm WD. Influence of enamel matrix derivative on primary CD4+ T-helper lymphocyte migration, CD25 activation, and apoptosis. J Periodontol. 2009; 80(9):1524-33, EpubSep 2009. IF: 2.192
  • Király M, Porcsalmy B, Pataki A, Kádár K, Jelitai M, Molnár B, Hermann P, Gera I, Grimm WD, Ganss B, Zsembery A, Varga G. Simultaneous PKC and cAMP activation induces differentiation of human dental pulp stem cells into functionally active neurons. Neurochem Int. 2009 Sep;55(5):323-32. Epub Apr 5, 2009. IF: 3.541
  • Arnold WH., S Becher, D Widera, M Jacob, HG Mannherz, Th Dittmar and WD Grimm. Morphological characterization of periodontium-derived human stem cells. Ann Anat 2010; 192:215–219, dx.doi.org/10.1016/j.aanat.2010.05.004. IF: 0.877
  • Grimm WD, A Dannan, S Becher, G Gassmann, WH Arnold, G Varga, Th Dittmar. The Ability of Human Periodontium-derived Stem Cells to Regenerate Periodontal Tissues-A Preliminary in vivo Investigation. Int. J Periodont. Rest. Dentistry 30: 2011, Vol. 31, Nr. 6, e94-e101. IF: 1.702
  • Keeve PL, Dittmar T, Gassmann G, Grimm WD, Niggemann B, Friedmann A. Characterization and analysis of migration patterns of dentospheres derived from periodontal tissue and the palate Characterization and analysis of migration patterns of dentospheres derived from periodontal tissue and the palate. J Periodontal Res. 2013 Jun;48(3):276-85. doi: 10.1111/jre.12005. Epub 2012 Oct 3. IF: 1.99
  • Grimm, W.-D., Plöger, M., Schau, I., Vukovic, M.A., Sirak, S.V., Shchetinin E.V. Complex, three-dimensional reconstruction of critical size defects following delayed implant placement using stem cell-containing subepithelial connective tissue graft and allogenic human bone blocks for horizontal alveolar bone augmentation: A case report as proof of clinical study principles. Medical News of North Caucasus 2014 9 (2), 131-133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904707876&partnerID=40&md5=f08a32f4e104837af9ea73f3953a4023
  • Grimm, W.D., Dannan, A., Giesenhagen, B., Schau, I., Varga, G., Vukovic, M.A., Sirak, S.V.Translational research: Palatal-derived ecto-mesenchymal stem cells from human palate: A new hope for alveolar bone and cranio-facial bone reconstruction. Inter J Stem Cells 2014 7 (1), 23-29. doi: 10.15283/ijsc.2014.7.1.23 http://www.scopus.com/inward/record.url?eid=2-s2.0-84901672088&partnerID=40&md5=9a032758b961fbeaa8b34cd388aa63cd
  • Grimm, W.-D., Plöger, M., Schau, I., Vukovic, M.A., Shchetinin, E.V., Akkalaev, A.B., Arutunov, A.V., Sirak, S.V. Prefabricated 3D allogenic bone block in conjunction with stem cell-containing subepithelial connective tissue graft for horizontal alveolar bone augmentation: A case report as proof of clinical study principles. Medical News of North Caucasus 2014 9 (2), pp. 175-178. http://www.scopus.com/inward/record.url?eid=2-s2.084904632350&partnerID=40&md5=57a4cfb02fbfd8bfb43d363f39240177
  • Grimm WD, B. Giesenhagen, S. Hakki, I. Schau, S. Sirak, A. Sletov, G. Varga, M. A. Vukovic, D. Widera. Translational Research and Therapeutic Applications of Neural Crest-Derived Stem Cells in Regenerative Periodontology. Curr Oral Health Rep 2015 DOI 10.1007/s40496-015-0067-6
  • Grimm WD, E.V. Shchetinin, D.V. Bobrishev, S.V. Sirak. Quantifying analysis of advanced glycosylation end products (ages) expression in periodontitis patients with diabetes type II. Medical News of North Caucasus 2015, vol. 10 Issue 2, 111-115 https://doi.org/10.14300/mnnc.2015.10042
  • Grimm Wolf-Dieter; Tilman Fritsch; Bernd Giesenhagen; Sergey Sirak; Alexandr Sletov; Magomet Aybazov; S. Tebyakina; Evgeny Shchetinin; Alexander Vukovic; Ivan Koshel. Neural crest-related stem cells of oral origins in vitro and used in osteoporotic sheep model- to be investigated due to therapeutic effects in alveolar bone regeneration. Medical News of North Caucasus 2016, vol. 11 Issue 2, 192-196, DOI – http://dx.doi.org/10.14300/mnnc.2016.11034
  • Grimm, W. D., S. V. Sirak, A. A. Adamchik, M. M. Aybazov, D. V. Bobryshev, N. N. Didenko, M. O. Didenko, T. Fritsch, B. Giesenhagen, I. V. Koshel, G. G. Petrosyan, E. V. Shchetinin, A. G. Sirak, A. A. Sletov, S. V. Tebyakina, and O. V. Vladimirova, “Osteoporotic Sheep mandibular model for comparative alveolar bone healing research. A proof of principle study”. Med. News North Caucasus, 2017, DOI – https://doi.org/10.14300/mnnc.2017.12091
  • Zeuner Marie-Theres, Liam Turner, David Humphries, Sokratis Stergiadis, Taryn Morash, Ketan Patel, Wolf-Dieter Grimm, Darius Widera. Isolation and Characterisation of Adult Ovine Neural Crest-Derived Stem Cells from Palatal Tissue. Front. Bioeng. Biotechnol. 2018, https://doi.org/10.3389/fcell.2018.00039
  • Sirak S, T Fritsch, B Giesenhagen, E Shchetinin, A Sletov, WD Grimm. Osteogenic Potential of Porous Titanium. An Experimental Study in Sheep. J Natl Med Assoc. 2018 Dec 21. pii: S0027-9684(17)30066-4. doi: 10.1016/j.jnma.2018.11.003. [Epub ahead of print]
  • Grimm WD, E Benlidayi, AA Dolgalev, MV Vukovic, T Fritsch. Osseointegration of Zirconium Dioxide Implants with Microrough Surface Topography compared to Titanium Implants - A Histological Study on Sheep. Biomed J Sci & Tech Res 16(1)-2019. BJSTR. MS.ID.002796.
  • Skurikhin E, O Pershina, A Pakhomova, E Pan, Vyacheslav A Krupin, N Ermakova, O Vaizova, A Pozdeeva, M Zhukova, V Skurikhina, WD Grimm, A Dygai. Endothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary Disease. Int. J. Mol. Sci. 2019, 20, 1105; doi:10.3390/ijms20051105
  • Grimm W.-D., N. Didenko, T. Fritsch, B. Giesenhagen, M.A. Vukovic. Effect of human neural crest-related stem cell homing (hNCSCs homing) on the mineralization of newly formed alveolar bone using an allogen bone substitute. Biomed J Sci & Tech Res (BJSTR) 2019 Volume 14 Issue 5.

W.-D. Grimm, Perio Publications since 2014 as PI

  • Mikrobiologische Beobachtung zur Periimplantitistherapie. Studie mit resorbierbaren mikroabrasiven Pulversystemen. Wirksamkeit der Pulverstrahlsysteme in der parodontalen Erhaltungstherapie. Implantologie Journal 1&2 | 2018
  • Wirksamkeit der Pulverstrahlsysteme in der parodontalen Erhaltungstherapie. ZWP Zahnarzt Wirtschaft Praxis – 11/2017
  • Osseointegration von Zirkoniumdioxid- und Titanimplantaten. Eine histologische Untersuchung im Vergleich. Implantologie Journal 11 | 2017
  • Knochenersatzmaterialien und periimplantärer Knochen-Eine Literaturanalyse. Implantologie Journal 9 | 2017, Jahrbuch Implantologie 2018
  • Osteogenic Potential of Porous Titanium: An Experimental Study in Sheep J Dent Res 2017, 96: special issue A, 1332
  • Osseointegration of Newly Developed Ceramic Implants in Osteoporotic Sheep. J Dent Res 2017, 96: special issue A, 3915
  • Osteoporotic Sheep Mandibular Model for Comparative Dental Implant Research. J Dent Res 2017, 96: special issue A, 2369
  • Neural crest-related stem cells of oral origins in vitro and used in osteoporotic sheep model for being investigated due to therapeutic effects in alveolar bone regeneration. Medical News of North Caucasus, DOI: 10.14300/mnnc.2016.11034, EID: 2-s2.0-84984820192
  • Translational Research and Therapeutic Applications of Neural Crest-Derived Stem Cells in Regenerative Periodontology. Current Oral Health Report 2015-09-23, DOI: 10.1007/s40496-015-0067-6
  • Allogene Knochenblockaugmentation bei Parodontitispatienten, Teil 1: Zielsetzung und Methode. Implantologie Journal 2015-05
  • Allogene Knochenblockaugmentation bei Parodontitispatienten Teil 2: Ergebnisse und Diskussion Implantologie Journal 2015-04
  • Allogene Knochenblockaugmentation unter Einsatz einer natürlichen Stammzellressource. Oralchirurgie Journal 2015-02
  • Quantifying analysis of advanced glycosylation end products (ages) expression in periodontitis patients with diabetes type II. Medical News of North Caucasus 2015, DOI: 10.14300/mnnc.2015.10042, EID: 2-s2.0-84937799165
  • Innovative Verfahren in der konservativen Parodontitis-/ Periimplantitistherapie, Teil 1. Zahnarzt Wirtschaft Praxis, 2014-05
  • Innovative Verfahren in der konservativen Parodontitis-/ Periimplantitistherapie, Teil 2. Zahnarzt Wirtschaft Praxis, 2014-04
  • Translational research: Palatal-derived ecto-mesenchymal stem cells from human palate: A new hope for alveolar bone and cranio-facial bone reconstruction. International Journal of Stem Cells 2014, DOI: 10.15283/ijsc.2014.7.1.23, EID: 2-s2.0-84901672088
  • Prefabricated 3D allogenic bone block in conjunction with stem cell-containing subepithelial connective tissue graft for horizontal alveolar bone augmentation: A case report as proof of clinical study principles. Medical News of North Caucasus 2014, DOI: 10.14300/mnnc.2014.09050, EID: 2-s2.0-84904632350
  • Complex, three-dimensional reconstruction of critical size defects following delayed implant placement using stem cell-containing subepithelial connective tissue graft and allogenic human bone blocks for horizontal alveolar bone augmentation: A case report as proof of clinical study principles. Medical News of North Caucasus 2014, DOI: 10.14300/mnnc.2014.09037, EID: 2-s2.0-8490470
Forschung

During his active research time as visiting research fellow at the Center for Oral and Systemic diseases (Director: Prof. Dr. St. Offenbacher) from 1997 up to 1998 and later on as Adjunct Professor of Periodontology (1998-2005) at the Department of Periodontology (Professor and Chair: Prof Dr. R. Williams) at the University of North Carolina at Chapel Hill, Prof. Grimm has developed rodent (rat and mice) animal models including animal treatment and experimental surgery (titanium chamber model); histological techniques (organ/tissue/cell isolation, fixation, processing for light/scanning electron microscopy, embedding, sectioning, specific/differential staining) and radioactive labeling in vivo/in vitro, autoradiography; for the investigation of periodontitis related to systemic diseases and for periodontal regeneration, now established in cooperation with the Anatomy and the Institute of Immunology, and the Animal facility Campus Witten of the Faculty of Health.

Since 2006 he focused on Stem cells in Regenerative Medicine. In standardized animal model, he investigated stem cell-supported periodontal and alveolar bone regeneration in nude rat. In general, his current stem cell research is focused on adult (somatic) stem cells and the regulation of their fundamental biological properties including differentiation, proliferation, and migration. We are further interested in the impact of pro- and anti-inflammatory signals on mesenchymal stem cells (progenitor of bone, fat and cartilage tissue) and neural crest-derived cells (progenitor of e.g. pigment cells and bones within the head region). Among others, my research team wants to address the following questions:

  • How do inflammation and infection influence stem cell-mediated regeneration of the bone tissues? Are pro- and anti-inflammatory signals beneficial or harmful to adult stem cells?
  • What is the ideal stem cell type for personalized regenerative medicine?
  • It is possible to increase the regenerative potential of autologous (belonging to the given patient), tissue-resident stem cells by manipulating the inflammatory balance?
  • Can such de-differentiation approach be used within Regenerative Medicine?
  • What are the best conditions and methods to cultivate stem cells (3D vs 2D culture, biomaterials)
  • What are the best techniques for vertical and horizontal augmentations of alveolar bone defects using bone substitutes as carrier material for human oral-derived neural crest-related stem cells
Weitere Informationen

Professional Activities and Memberships
Membership National and International Associations

  • since 2008: Stem Cell Network North Rhine Westphalia, Germany
  • since 1998: International Academy of Periodontology (IAP)
  • since 1998: American Academy of Periodontology (AAP)
  • since 1991: International Association of Dental Research (IADR)
  • since 1991: Working Group Periodontology, International Association of Dental Research
  • since 1991: Continental European Division (CED) of IADR
  • since 1968: Deutsche Gesellschaft für Zahn-, Mund- und Kieferheilkunde (DGZMK)
  • since 1975: Deutsche Gesellschaft für Parodontologie (DGP)
  • since 1991: Arbeitsgemeinschaft für Grundlagenforschung (AfG)
  • since 1991: Deutsche Gesellschaft für Zahnerhaltung (DGZ)
  • since 1992: Vereinigung der Hochschullehrer für Zahn-, Mund- und Kieferheilkunde (VHZMK)

ad-hoc reviewer for
Journal of Periodontal Research <https://publons.com/author/edit/#profile-settings>

Die Universität Witten/Herdecke ist durch das NRW-Wissenschaftsministerium unbefristet staatlich anerkannt und wird – sowohl als Institution wie auch für ihre einzelnen Studiengänge – regelmäßig akkreditiert durch: