Faculty of Health

    Chair of Physiology, Pathophysiology and Toxicology

    The focus of research of the Chair of Physiology, Pathophysiology and Toxicology at Witten/Herdecke University is to study kidney function in health and disease. Teaching covers human physiology and pathophysiology for medical and dental students as well as molecular medicine for medical, dental and basic science students. A further aim is to integrate research and teaching.

    Our research encompasses innovative projects in molecular and cellular physiology, pathophysiology and toxicology, as well as in molecular medicine, that are investigated using state-of-the-art methodology. The chair is characterized by national and international co-operations and funding support (e.g. German Research Foundation [DFG]). State-of-the-art molecular and cellular experimental techniques are used to elucidate scientific problems that may contribute to a better understanding and development of cures for various kidney diseases (translational research). New research findings and experimental techniques are integrated into the curriculum and training of students.

    The Chair of Physiology, Pathophysiology and Toxicology at Witten/Herdecke University is involved in teaching of the model curriculum (“Modellstudiengang”) in the preclinical study phase (semesters 1-4) of the medical degree program.

    Teaching modules cover relevant aspects of molecular, cellular and organ physiology and pathophysiology. The aim of the interactive teaching sessions is to convey a fundamental understanding of physiological processes at the cellular and molecular levels, their implications for the normal function of organs and the human body, as well as their role in the pathogenesis of diseases and in the development of causal therapy approaches.

    The essential elements of the teaching modules are:
    Teaching staff:
    Research Interests

    The focus of research is the physiology, pathophysiology and toxicology of epithelia. Molecular and cellular aspects of normal function of epithelial layers are studied, in order to determine their importance for the including their role in the pathogenesis and treatment of diseases of these tissues. The projects are carried out at the molecular and cellular level using state-of-the-art molecular biological, biochemical, biophysical and microscopy techniques at the molecular and cellular level. These methods are complemented by investigations on isolated tissue and whole organisms.

    Basic research forms the foundation and core of the Chair of Physiology, Pathophysiology and Toxicology. Details of current and past research projects can be downloaded from the project database of the Faculty for Health at the University of Witten/Herdecke. 

    Research Goals
    Research Group Thévenod
    Research Group Lee
    Research Group Wolff

    Selected publications of the past five years

    Year
    Title
    Author
    Type
    2020
    Cell Organelles as Targets of Mammalian Cadmium Toxicity

    Lee WK, Thévenod F

    Scientific article (journals)
    2019
    Inverse Regulation of Lipocalin-2/24p3 Receptor/SLC22A17 and Lipocalin-2 Expression by Tonicity, NFAT5/TonEBP and Arginine Vasopressin in Mouse Cortical Collecting Duct Cells mCCD(cl.1): Implications for Osmotolerance

    Probst S, Scharner B, McErlean R, Lee WK, Thévenod F

    Scientific article (journals)
    2019
    Cadmium Complexed with β2-Microglubulin, Albumin and Lipocalin-2 rather than Metallothionein Cause Megalin:Cubilin Dependent Toxicity of the Renal Proximal Tubule.

    Fels J, Scharner B, Zarbock R, Zavala Guevara IP, Lee WK, Barbier OC, Thévenod F

     

    Scientific article (journals)
    2019
    Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin-cubilin complex and transferrin receptor 1.

    Smith CP, Lee WK, Haley M, Poulsen SB, Thévenod F, Fenton RA

    Scientific article (journals)
    2019
    Oncogenic PITX2 facilitates tumor cell drug resistance by inverse regulation of hOCT3/SLC22A3 and ABC drug transporters in colon and kidney cancers.

    Lee WK, Thévenod F

     

    Scientific article (journals)
    2018
    Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection

    Betten R, Scharner B, Probst S, Edemir B, Wolff NA, Langelueddecke C, Lee WK, Thévenod F

    Scientific article (journals)
    2018
    Intrauterine Exposure to Cadmium Reduces HIF-1 DNA-Binding Ability in Rat Fetal Kidneys

    Jacobo-Estrada T, Cardenas-Gonzalez M, Santoyo-Sánchez MP, Thevenod F, Barbier O

    Scientific article (journals)
    2018
    Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis

    van Swelm RPL, Vos M, Verhoeven F, Thévenod F, Swinkels DW

    Scientific article (journals)
    2018
    A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese

    Wolff NA, Garrick MD, Zhao L, Garrick LM, Ghio AJ, Thévenod F

    Scientific article (journals)
    2017
    Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells

    Lee WK, Probst S, Santoyo-Sánchez MP, Al-Hamdani W, Diebels I, von Sivers JK, Kerek E, Prenner EJ, Thévenod F

    Scientific article (journals)
    2016
    Renal handling of circulating and renal synthesized hepcidin and its protective effects against hemoglobin-mediated kidney injury.

    van Swelm, R.P.L., Wetzels, J.F.M., Verweij, V.G.M., Coby, M.M., Laarakkers, J.C.L.M., van der Wijst, J., Thévenod, F., Masereeuw, R., Swinkels, D.W.

    Scientific article (journals)
    2016
    Biochemical and structural characterization of the interaction between the siderocalin NGAL/LCN2 and the N-terminal domain of its endocytic receptor SLC22A17

    Cabedo Martinez, A.-I., Weinhäupl, K., Lee, W.-K., Wolff, N.A., Storch, B., Zerko, S., Konrat, R., Kozminski, W., Breuker, W., Thévenod, F., Coudevylle, N.

    Scientific article (journals)
    2015
    Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney.

    Nair, A.R., Lee, W.-K., Smeets, K., Swennen, Q., Sanchez, A., Thévenod, F., Cuypers, A.

    Scientific article (journals)
    2014
    Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1).

    Wolff, N.A., Ghio, A.J., Garrick, L.M., Garrick, M.D., Zhao, L., Fenton, R.A., Thévenod, F.

    Scientific article (journals)

    Selection of review articles of the last five years

    Year
    Title
    Author
    Type
    2019
    Channels, transporters and receptors for cadmium and cadmium complexes in eukaryotic cells: myths and facts.

    Thévenod F, Fels J, Lee WK, Zarbock R

    Scientific article (journals)
    2018
    Cadmium Interaction with Animal Cells.

    Thévenod F., Petering D., M. Templeton D., Lee WK., Hartwig A. (eds)

    Book editorship
    2018
    Membrane Transport Proteins and Receptors for Cadmium and Cadmium Complexes.

    Thévenod F.

    Book contribution
    2018
    Cell Organelles as Targets of Cadmium Toxicity.

    Lee WK

    Book contribution
    2018
    Cadmium Handling, Toxicity and Molecular Targets Involved during Pregnancy: Lessons from Experimental Models

    M Santoyo-Sánchez, F Thévenod, O Barbier

    Book contribution
    2018
    Iron and Its Role in Cancer Defense: A Double-Edged Sword

    Thévenod F

    Scientific article (journals)
    2018
    Metallo-Drugs: Development and Action of Anticancer Agents: Development and Action of Anticancer Agents

    Imogen Riddell, Stephen J Lippard, Victor Brabec, Jana Kasparkova, Vijay Menon, Nicholas P Farrell, V Venkatesh, Peter J Sadler, Anil K Gorle, Erica J Peterson, Susan Berners-Price, Enzo Alessio, Luigi Messori, Maria V Babak, Wee Han Ang, Angela Casini, Raymond Wai-Yin Sun, Ingo Ott, Edit Tshuva, Maya Miller, Debbie Crans, Lining Yan, Allison Haase, Xiaogai Yang, Christopher Chitambar, Lucia Cardo, Michael John Hannon, Ramon Vilar, Matthew P Sullivan, Hannah U Holtkamp, Christian G Hartinger, Ulrich Schatzschneider, Frank Thévenod, Delphine Denoyer, Sharnel AS Clatworthy, Michael Cater, Silvia Ziliotto, Olivia Ogle, Kathryn M Taylor

    Book
    2017
    Sphingolipid abnormalities in cancer multidrug resistance: Chicken or egg?

    Lee WK, Kolesnick RN.

    Scientific article (journals)
    2016
    Iron transport in the kidney: Implications for physiology and cadmium nephrotoxicity.

    Thévenod, F., Wolff, N.A.

    Scientific article (journals)

    Other people

    Name FunKtion E-Mail

    Marie Henschen
    +49 (0)2302 / 926-313

    Doktorandin Marie.Henschen@uni-wh.de

    Calista Ow
    +49 (0)2302 / 926-313

    Austauschstudentin Calista.Ow@uni-wh.de

     

    Contact
    Univ.-Prof. Dr. Frank Thevenod
    Contact

    Univ.-Prof. Dr.med.
    Frank Thevenod , PhD

    Fakultät für Gesundheit (Department für Humanmedizin)
    Lehrstuhl für Physiologie, Pathophysiologie und Toxikologie
    Institutsleitung

    Phone: +49 (0)2302 / 926-221

    E-Mail: frank.thevenod@uni-wh.de

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    Die Universität Witten/Herdecke ist durch das NRW-Wissenschaftsministerium unbefristet staatlich anerkannt und wird – sowohl als Institution wie auch für ihre einzelnen Studiengänge – regelmäßig akkreditiert durch: