SCOPE

The project "Sepsis-inducedCoagulopathyin Hemato-OncologicPatiEnts" (SCOPE)is investigating haemostaseological changes in patients with haemato-oncological diseases with and without sepsis.

Sepsis and septic shock are severe courses of infections that are associated with a high mortality rate. Due to physiological interactions between inflammation and the coagulation system, haemostaseological changes play a key role in the pathophysiology of sepsis.

In recent years, the term sepsis-induced coagulopathy (SIC) has therefore been established, which is defined as the maximum form of disseminated intravascular coagulopathy as a result of sepsis.

In oncology, patients are particularly susceptible to severe infections due to cancer-related and treatment-related immunosuppression, especially in the case of neutropenia. Here, sepsis is responsible for a high proportion of cancer- and treatment-associated mortality.

The aim of the project is to better understand how exactly blood coagulation changes in these critically ill patients. This should enable complications to be recognised early and treated more effectively.