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Metallo-Drugs: Development and Action of Anticancer Agents: Development and Action of Anticancer Agents



Imogen Riddell, Stephen J Lippard, Victor Brabec, Jana Kasparkova, Vijay Menon, Nicholas P Farrell, V Venkatesh, Peter J Sadler, Anil K Gorle, Erica J Peterson, Susan Berners-Price, Enzo Alessio, Luigi Messori, Maria V Babak, Wee Han Ang, Angela Casini, Raymond Wai-Yin Sun, Ingo Ott, Edit Tshuva, Maya Miller, Debbie Crans, Lining Yan, Allison Haase, Xiaogai Yang, Christopher Chitambar, Lucia Cardo, Michael John Hannon, Ramon Vilar, Matthew P Sullivan, Hannah U Holtkamp, Christian G Hartinger, Ulrich Schatzschneider, Frank Thévenod, Delphine Denoyer, Sharnel AS Clatworthy, Michael Cater, Silvia Ziliotto, Olivia Ogle, Kathryn M Taylor

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum (II)(cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt (IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru (II/III), Au (I/III), Ti (IV), V (IV/V), and Ga (III) including also the essential metal ions Fe (II/III), Cu (I/II), and Zn (II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs …


Art des Beitrags:
2018 , k.A.

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